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. 2010 Jun 10;84(17):8673–8682. doi: 10.1128/JVI.00641-10

TABLE 1.

Comparison of ssAAV and scAAV transduction, genome circularization, and integration

Mutation Fold differencea
ssAAV
scAAV
Transductionb Circularizationc Integrationd Transduction Circularization Integration
ATM +2.6 1.0 −3.0 +6.6 +1.2 −1.1
ATR +1.3 1.0 +1.2 1.0 1.0 +1.3
DNA-PKCS −8.0 −8.4 −8.5 −2.5 −2.2 −10.5
a

Positive values indicate an increased percentage of GFP-positive cells relative to the wt. Negative values indicate a decrease relative to the wt. A value of 1.0 indicates no change.

b

Fold difference in intact GFP vector transduction between wt and mutant cell lines (data are from Fig. 1, 4, and 5).

c

Fold difference in circularized genomes between wt and mutant cell lines (data are from Fig. 1, 4, and 5).

d

Fold difference in integrated genomes between wt and mutant cell lines (data are from Fig. 8).