TABLE 1.
Mutation | Fold differencea |
|||||
---|---|---|---|---|---|---|
ssAAV |
scAAV |
|||||
Transductionb | Circularizationc | Integrationd | Transduction | Circularization | Integration | |
ATM | +2.6 | 1.0 | −3.0 | +6.6 | +1.2 | −1.1 |
ATR | +1.3 | 1.0 | +1.2 | 1.0 | 1.0 | +1.3 |
DNA-PKCS | −8.0 | −8.4 | −8.5 | −2.5 | −2.2 | −10.5 |
Positive values indicate an increased percentage of GFP-positive cells relative to the wt. Negative values indicate a decrease relative to the wt. A value of 1.0 indicates no change.
Fold difference in intact GFP vector transduction between wt and mutant cell lines (data are from Fig. 1, 4, and 5).
Fold difference in circularized genomes between wt and mutant cell lines (data are from Fig. 1, 4, and 5).
Fold difference in integrated genomes between wt and mutant cell lines (data are from Fig. 8).