TABLE 1.
Serological parameters and pulmonary viral titers achieved by mice that received i.n. administration of 1,500 ng of an unadjuvanted or PIKA-adjuvanted H5N1 subunit vaccine
| Amt of PIKA (μg) | Mice | Serum ELISA Ab titer (log10) | Serum MN Aba titer (log2) | IgG2a/IgG1 ratio | Pulmonary viral titer (TCID50/g) |
|---|---|---|---|---|---|
| 0 | M1 | 4.0 | 5.3 | 1:7.1 | 4.5 |
| M2 | 4.0 | 5.0 | 1:8.3 | 5.2 | |
| M3 | 4.5 | 10.7 | 1:4.5 | 5.2 | |
| M4 | 5.0 | 8.0 | 1:3.3 | 1.5 | |
| M5 | 4.5 | 8.0 | 1:2.4 | 1.5 | |
| 100 | M1 | 5.0 | 9.3 | 1:1.5 | 1.5 |
| M2 | 5.0 | 9.8 | 1:1.4 | 1.5 | |
| M3 | 3.5 | 8.8 | 1:0.9 | 1.5 | |
| M4 | 5.0 | 9.0 | 1:1.2 | 1.5 | |
| M5 | 5.0 | 8.8 | 1:2.0 | 1.5 |
a
MN Ab, microneutralizing antibody.