FIG. 6.

The effect of mannosidase I inhibitor, DMJ, on the interaction of MBL with SARS-CoV. (A) Binding of wild-type (WT) and N330Q mutant SARS-S pseudoviruses, produced in the presence or absence of 1 mM DMJ, to rMBL-coated plates (10 μg ml⁻¹). (B) MBL-mediated neutralization of wild-type and N330Q mutant pseudoviruses, produced in the presence or absence of 1 mM DMJ. The percentage of infection ± standard deviations is presented for a single experiment carried out in triplicate. Similar results were obtained in three independent experiments.