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. 2010 Jun 9;285(33):25154–25160. doi: 10.1074/jbc.M110.116897

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Effect of caveolin-1 on CLP-induced lung injury. a, effect of caveolin-1 on MPO activity. Caveolin-1 null mice (solid triangle) and wild type littermates (solid square) were treated with CLP for 2, 4, 8, and 20 h, and MPO activity in lung was quantified (n = 6 per group, mean ± S.D.). b, effect of caveolin-1 on pulmonary edema formation. Caveolin-1 null mice (solid) and wild type littermates (open) were treated with CLP or sham. After 8 h, the lung was collected, and wet/dry ratio was determined (n = 5 per group, mean ± S.D.). c, effect of caveolin-1 on pulmonary microvascular permeability. Caveolin-1 null mice (solid) and wild type littermates (open) were treated with CLP or sham for 8 h. Then, the lungs were isolated, and lung microvascular permeability was assessed by measuring microvessel infiltration coefficient (K_f,c) (n = 5 per group, mean ± S.D.).