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WRN(1–333) is trimeric whereas smaller nuclease constructs are primarily monomeric. A, overlay of three separate S-200 gel filtration elution profiles for WRN(1–333) (red), WRN(1–236) (blue), and WRN(38–236) (black) in buffer containing 0.5 m NaCl. B, standard curve based on ferritin (440 kDa), aldolase (158 kDa), albumin (67 kDa), and chymotrypsinogen A (25 kDa). The elution volume intercepts for three WRN constructs are indicated by color-coded arrows.
