FIGURE 6.

The antioxidant activity and lipophilic nature of α-tocopherol are required to protect cells from edelfosine. Wild type (BY4741) cells grown to mid-log phase were either untreated or incubated with edelfosine (10 μg/ml) alone or in combination with 25 μm of each of the following compounds: α-TOC, Me-α-TOC, chromanol, or methylated chromanol (Me-Chromanol). A, growth, and B, viability were determined as described in the legend to Fig. 3. Results are presented as the mean ± S.D. of a representative experiment performed at least three times.