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pH-dependent lipid mixing of eLVP produced from Caco-2 cells (A) or Huh-7.5 cells (B). TRL particles (350 ng/ml apoB concentration) from untransduced (open bars) or E1-E2-transduced cells (solid bars) were added to a cuvette containing phosphatidylcholine:cholesterol:R18 liposomes, and lipid mixing was recorded at the indicated pH values. Initial rates of lipid mixing were then normalized, with 1 corresponding to the rate measured at pH 7.4.
