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. Author manuscript; available in PMC: 2011 Jul 8.
Published in final edited form as: J Phys Chem B. 2010 Jul 8;114(26):8817–8825. doi: 10.1021/jp104258d

Figure 4.

Figure 4

Illustration of the structures for the characterized acylation reaction stage. ES, enzyme-substrate complex; TS1, the first transition state; TI1, tetrahedral intermediate; TS1′, the second transition state in acylation; EA1, acylated enzyme. Two representative configurations of TI1 are shown.