Table 3.
Features of AML96 GFI136S and GFI136N patients
| GFI136N (n) | GFI136S (n) | P | |
|---|---|---|---|
| Number | 40 | 337 | |
| Median age, y | 53.5 (40) | 57 (337) | .746 |
| Sex, % male | 42.5 (17) | 51 (172) | .307 |
| Leukocytes, per fl | 49 (40) | 39 (337) | .652 |
| Blast percentage | 61 (35) | 62 (303) | .618 |
| LDH, IU | 542 (38) | 691 (323) | .751 |
| Platelets, per fl | 92 (40) | 77 (337) | .225 |
| FLT3 status negative, %* | 90 (40) | 88 (332) | .688 |
| NPM1 mutations, % | 64 (14) | 50 (93) | .64 |
| PTPN11 mutations, % | 16 (3) | 3 (5) | .03 |
| MLL PTD, %† | 6 (1) | 7 (11) | 1 |
The characteristics of GFI136 homozygous and carriers of the GFI136N allele with regard to different parameters are described.
AML indicates acute myeloid leukemia; GFI1, Growth Factor Independence 1; LDH, lactate dehydrogenase; MLL, mixed-lineage leukemia; and PTD, partial tandem duplication.
*
No internal tandem duplication mutation.
†
PTD mutations.