Table 3.

Linear mixed models of change in MMSE score over time based on poor performance on single cognitive domains

Domain	Delayed recall		Attention		Orientation for time		Orientation for place
Variable	Estimatea	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value
Baseline age	−0.0858	0.0142	−0.0971	0.0082	−0.1044	0.0009	−0.1249	0.0002
Female	0.0083	0.9892	−0.4295	0.5035	0.2970	0.5912	0.2577	0.6578
Education ≤ 8 yrs	−2.4037	0.0003	−1.1834	0.0988	−2.4323	<0.0001	−1.5425	0.0146
9 ≤ education ≤ 12	−0.6004	0.3086	−0.2954	0.6359	−0.4114	0.4396	−0.6399	0.2538
Domain (above median)	3.5890	<0.0001	3.3335	<0.0001	5.2985	<0.0001	5.0991	<0.0001
Time	−1.5682	<0.0001	−1.4579	<0.0001	−1.7799	<0.0001	−1.5517	<0.0001
Domain*time	0.1776	0.1420	−0.0951	0.4399	0.4635	0.0001	0.1054	0.3768

^aEstimates represent the extent of annual increase on the MMSE.