Table 4.

Linear mixed models of change in MMSE score over time based on poor performance on pairs of cognitive domains

Domain combination	Domain 1	Delayed recall	Domain 1	Delayed recall	Domain 1	Delayed recall	Domain 1	Attention	Domain 1	Attention	Domain 1	Orientation for time
	Domain 2	Attention	Domain 2	Orientation for time	Domain 2	Orientation for place	Domain 2	Orientation for time	Domain 2	Orientation for place	Domain 2	Orientation for place
Variable	Estimatea	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value
Baseline age	−0.0666	0.0545	−0.0872	0.0050	−0.1045	0.0012	−0.0875	0.0055	−0.1097	0.0010	−0.1101	0.0003
Female	−0.2945	0.6251	0.2825	0.6022	0.2868	0.6103	−0.0973	0.8600	−0.1209	0.8348	0.3854	0.4672
Education ≤ 8 yrs	−1.3083	0.0520	−2.4971	<0.0001	−1.7151	0.0051	−1.6592	0.0070	−0.6000	0.3546	−1.9999	0.0005
9 ≤ Education ≤ 12	−0.4241	0.4690	−0.4636	0.3743	−0.6769	0.2119	−0.3120	0.5591	−0.4423	0.4327	−0.5106	0.3165
Domain 1(above median)	3.4949	<0.0001	1.6096	0.0358	3.0971	<0.0001	2.6058	0.0003	2.7374	0.0002	4.3719	<0.0001
Domain 2(above median)	3.1882	<0.0001	4.3152	<0.0001	4.9403	<0.0001	4.8033	<0.0001	4.8446	<0.0001	3.9984	<0.0001
Domain 1*domain 2	0.3815	0.7180	0.7939	0.4316	−1.0105	0.3191	0.5168	0.5973	0.1517	0.8822	−1.0233	0.3179
Time	−1.3418	<0.0001	−1.8720	<0.0001	−1.4743	<0.0001	−1.5731	<0.0001	−1.5988	<0.0001	−1.7532	<0.0001
Domain 1*time	−0.2542	0.1852	0.3430	0.0911	−0.1841	0.3350	−0.3966	0.0338	0.0851	0.6299	0.4988	0.0045
Domain 2*time	−0.3893	0.0148	0.6008	0.0001	−0.1731	0.2724	0.2313	0.2128	0.3217	0.0858	−0.0681	0.7335
Domain 1*domain 2*time	0.7002	0.0046	−0.4012	0.1135	0.5717	0.0225	0.4247	0.0838	−0.3557	0.1450	−0.0008	0.9976

^aEstimates represent the extent of annual increase on the MMSE.