Table 1.

Synthesis of thiolactone-isatin hybrids 3 and tetracycles 4.

Compd	R	n	(3:4)a	Yield (%)
3a	Br	1	100:0	9
3b	Cl	1	100:0	13
3c	F	1	100:0	14
3d	I	1	100:0	10
3e	CH3	1	100:0	26
3f	H	1	100:0	36
3g	H	2	100:0	18
3h, 4a	H	3	22:78	45b
3i, 4b	H	4	84:16	31b
3j, 4c	H	5	71:29	21b

^aDetermined from isolated yields;

^bCombined isolated yields of 3 and 4.