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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Immunol Rev. 2010 Jul;236:219–242. doi: 10.1111/j.1600-065X.2010.00923.x

Fig. 7. Mechanisms of PD-1-mediated T-cell tolerance.

Fig. 7

PD-L1 ligation of PD-1 following TCR stimulation results in two possible T-cell fates: diminished T-effector responses and augmented iTreg development, thus tipping the balance towards immunologic tolerance.