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Effects of loss of Atox1 on the distribution of Ctr1 (green) and polyubiquitin (red) in Atox1+/+ (top panel) and Atox1-/- (lower panel) cells. All cells were treated with 40 nM bortezomib for 4 h and then with either 300 μM Cu or 10 μM CDDP for 15 min. A rabbit polyclonal antibody to Ctr1 and a mouse monoclonal antibody to polyubiquitin conjugates were used. Nuclei were stained with Hoechst 33342. Yellow depicts co-localization of Ctr1 and polyubiquitin signals.
