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Distribution of Pt in subcellular fractions of Atox1+/+ and Atoxl-/- cells.
| Cell Fraction | Percent of total Pt in fraction, mean ± SEM | pmol Pt/mg protein, mean ± SEM | |||
|---|---|---|---|---|---|
| Atox1+/+ cells | Atox1-/- cells | Atox1+/+ cells | Atox1-/- cells | p Value* | |
| Cytosol | 70.1 ± 4.4 | 73.9 ± 6.6 | 21.4 ± 0.4 | 18.6 ± 0.5 | |
| Microsomal | 5.9 ± 0.8 | 6.1 ± 0.9 | 221.8 ± 10.9 | 176.3 ± 12.5 | <0.05 |
| Nuclear | 24.0 ± 4.6 | 20.0 ± 4.8 | 318.5 ± 21.6 | 160.1 ± 21.5 | <0.04 |
For difference in Pt content.
