Figure 6. YIRFamide enhances whole cell voltage-gated ICa/Ba in isolated S. mansoni muscle fibers.
(A) Both peak and sustained ICa/Ba increased in amplitude upon treatment with 1 µM YIRFamide. YIRFamide was applied as indicated with the shaded box. Data were normalized as described in Figure 4 and plotted as mean ± SEM. (B) Representative traces of ICa/Ba before, during and after application of the peptide show the enhancement of the current and the washout of the effect after the cessation of application. The dotted line denotes zero current level and the scale bar is 20 pA. The discontinuous time scale of the experiment is shown above traces, and each of the depolarizing pulses is 200 ms.