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. 2010 Aug 10;4(8):e790. doi: 10.1371/journal.pntd.0000790

Figure 8. Protein kinase C (PKC) inhibitors block the FMRFamide-like peptide (FLP)-induced contractions.

Figure 8

Concentration-response curves for the blockade of muscle fiber contractions by various PKC inhibitors show that the FLP-induced contractions use a PKC-dependent pathway. Both calphostin C (IC50 = 61 nM) and chelerythrine chloride (IC50 = 0.7 µM) block the contractions at concentrations well within the range attributed to specific PKC inhibition in other systems. RO 31–8220 also blocked the contractions, but at concentrations (IC50 = 1.54 µM) higher than are required for specific PKC inhibition in some mammalian systems. Data points represent mean ± SEM of % muscle fibers contracting, with n≥5 for each point.