Table 3. Expansion of selected GO categories during prolonged EBNA1 expression.
GO category | GO Level | Common | Short-term induced | Long-term induced | Stable | ||||
Biological process | No. of genes | P | No. of genes | P | No. of genes | P | No. of genes | P | |
Cellular component organization and biogenesis | 2 | 14 | 0.062 | 67 | <0.001 | 774 | <0.001 | 622 | <0.001 |
Establishment and/or maintenance of chromatin architecture | 5 | 12 | <0.001 | 24 | <0.001 | 144 | <0.001 | 93 | 0.001 |
Regulation of cellular process | |||||||||
Regulation of apoptosis | 5 | 4 | 0.100 | 14 | 0.020 | 146 | 0.003 | 137 | <0.001 |
Molecular function | |||||||||
Binding | 2 | 32 | 0.023 | 184 | 0.001 | 3017 | <0.001 | 2544 | <0.001 |
Adenyl nucleotide binding | 4 | 6 | 0.092 | 26 | 0.094 | 438 | <0.001 | 363 | <0.001 |
Catalytic activity | |||||||||
Nucleoside-triphosphatase activity | 6 | 4 | 0.094 | 16 | 0.011 | 157 | 0.009 | 134 | 0.020 |
Cellular component | |||||||||
Non-membrane-bound organelle | 2 | 13 | 0.029 | 40 | 0.075 | 510 | <0.001 | 403 | 0.019 |
Chromosome | 5 | 12 | <0.001 | 21 | 0.001 | 151 | <0.001 | 110 | <0.001 |