Table 4.
Results from gene-gene interaction analysis for risk of the metabolic syndromea
| Number | SNP | rs-number | Estimate | Standard error | p value | OR for SNP 1 by SNP 2 |
OR for SNP 2 by SNP1 |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP 2 = 0 (95% CI) |
SNP 2 = 1 (95% CI) |
SNP 2 = 2 (95% CI) |
SNP 1 = 0 (95% CI) |
SNP 1 = 1 (95% CI) |
SNP 1 = 2 (95% CI) |
||||||
| 1564 | SNP 1 | rs2073658 | −0.21 | 0.09 | 0.026 | ||||||
| SNP 2 | rs1729411 | −0.30 | 0.15 | 0.045 | 0.81 | 0.54 | 0.36 | 0.74 | 0.49 | 0.33 | |
| SNP 1 × SNP 2 | rs2073658 × rs1729411 | −0.41 | 0.18 | 0.024 | (0.67–0.97) | (0.34–0.86) | (0.16–0.81) | (0.55–0.99) | (0.27–0.89) | (0.13–0.83) | |
| 1497 | SNP 1 | rs2516839 | 0.06 | 0.08 | 0.472 | ||||||
| SNP 2 | rs3135506 | −0.04 | 0.23 | 0.870 | 1.06 | 0.66 | 0.40 | 0.96 | 0.60 | 0.37 | |
| SNP 1 × SNP 2 | rs2516839 × rs3135506 | −0.48 | 0.24 | 0.047 | (0.90–1.25) | (0.38–1.14) | (0.15–1.12) | (0.62–1.50) | (0.25–1.40) | (0.10–1.36) | |
a
Logistic regression model included the covariates sex (dichotomous), age, SNP 1, SNP 2 and SNP 1 × SNP 2 (all continuous). SNP coding: 0 = homozygous for major allele, 1 = heterozygous, 2 = homozygous for minor allele. After correction for multiple testing, none of the interactions remained significant.