Table 1.
GASP-1 interaction partners and their associated functions
| Interaction partners | Interaction |
Function |
Ref. No. | ||
|---|---|---|---|---|---|
| GST | CoIP | in vitro | in vivo | ||
| Angiotensin II receptor type 1 (ATI) | yes | n.d. | 35 | ||
| Bradykinin 1 receptor (B1R) | yes | yes | 46 | ||
| β1-AR | yes | n.d. | 47 | ||
| β2-AR | yes | no | competition with recycling proteins | 29 | |
| B-alaR (mutant β2-AR) | yes | yes | targeted degradation | 29 | |
| Calcitonin receptor (CALCR) | yes | n.d. | 47 | ||
| Cannabinoid 1 receptor (CB1R) | yes | yes | targeted degradation | agonist-induced receptor downreg-ulation in the spinal cord in mice and development of antinociceptive tolerance | 42, 43, 48 |
| Dopamine D2 receptor (D2R) | yes | yes | targeted degradation; reduced resensitization in rat neurons | increased receptor downregulation after chronic cocaine administration in GASP-1 KO mice | 7, 29, 40, 41, 45 |
| DOR | yes | yes | targeted degradation | 7 | |
| Dysbindin | n.d. | yes | 39 | ||
| Histamine H2 receptor (H2R)1 | yes | n.d. | 47 | ||
| 5-hydroxytryptamine 7 receptor (5-HT7) | yes | n.d. | 47 | ||
| κ-Opioid receptor (KOR) | yes | n.d. | 47 | ||
| μ-Opioid receptor truncated (MOR-TR) | yes | yes | targeted degradation | 29 | |
| M1 | yes | n.d. | increased receptor downregulation after chronic cocaine administration in GASP-1 KO mice | 41,47 | |
| M21 | yes | n.d. | increased receptor downregulation after chronic cocaine administration in GASP-1 KO mice | 41,47 | |
| Opioid receptor-like 1 (ORL1) | yes | n.d. | 47 | ||
| ORF74 | yes | n.d. | 35 | ||
| Tachikinin NK1 receptor (NK1) | yes | n.d. | 35 | ||
| Thromboxane A2α receptor (TXA2α) | yes | n.d. | 47 | ||
| US28 | yes | yes | targeted degradation; enhanced signaling | 35,44 | |
GST = In vitro binding to glutathione S-transferase fusion proteins; CoIP = coimmunoprecipitation; n.d. = not determined.
1
Low-affinity binding.