Table 6.
Mortality RR by presence of APOE41 for each disease group
| Number | Dead % | Rate ratio | 95% CI | ||
|---|---|---|---|---|---|
| ALS | APOE4 present | 16 | 62.5 | 1.96 | 0.89–4.31 |
| APOE4 absent (ref) | 48 | 70.8 | 1.00 | ||
| Possible | APOE4 present | 95 | 33.7 | 1.21 | 0.74–1.97 |
| AD | APOE4 absent (ref) | 86 | 46.5 | 1.00 | |
| Probable | APOE4 present | 452 | 39.6 | 1.11 | 0.86–1.41 |
| AD | APOE4 absent (ref) | 244 | 45.5 | 1.00 | |
| FTD | APOE4 present | 28 | 28.6 | 1.15 | 0.48–2.76 |
| APOE4 absent (ref) | 44 | 34.1 | 1.00 | ||
| LBD | APOE4 present | 24 | 58.3 | 3.51 | 1.16–10.58 |
| APOE4 absent (ref) | 22 | 27.3 | 1.00 | ||
| MCI | APOE4 present | 99 | 14.1 | 1.02 | 0.49–2.13 |
| APOE4 absent (ref) | 103 | 17.5 | 1.00 | ||
| PD | APOE4 present | 159 | 28.3 | 1.73 | 1.19–2.52 |
| APOE4 absent (ref) | 448 | 21.0 | 1.00 | ||
| Controls | APOE4 present | 203 | 8.4 | 1.28 | 0.69–2.40 |
| APOE4 absent (ref) | 368 | 9.5 | 1.00 | ||
1
Data adjusted for race, sex, and education via Cox regression with age as the time variable. Adjustment for comorbidity did not change results. APOE4 considered present if subject either heterozygous or homozygous.