Table 1.
Allele and genotype frequencies of frequent polymorphisms in NOS1AP*
| Polymorphisms# | Location | Number of alleles (frequency) | Number of Genotype (frequency) | |||||
|---|---|---|---|---|---|---|---|---|
| Allele 1 | Allele 2 | P (df = 1) | 11 | 12 | 22 | P (df = 2) | ||
| rs10918776 | Intron 2 | G | C | |||||
| SCZ | 100 (0.77) | 32 (0.23) | 0.46 | 42 | 22 | 5 | 0.57§ | |
| ASD | 117 (0.72) | 45 (0.28) | 0.06 | 39 | 37 | 4 | 0.06§ | |
| Controls | 142 (0.80) | 34 (0.20) | 57 | 28 | 3 | |||
| rs10800405 | Intron 3 | C | G | |||||
| SCZ | 91 (0.76) | 31 (024) | 0.92 | 37 | 25 | 3 | 0.98§ | |
| ASD | 102 (0.74) | 36 (0.26) | 0.63 | 34 | 33 | 1 | 0.60§ | |
| Controls | 113 (0.77) | 35 (0.23) | 43 | 29 | 3 | |||
| rs347306 and rs347307 | Intron 5 | C and T | T and C | |||||
| SCZ | 74 (0.56) | 60 (0.44) | 0.19 | 20 | 38 | 12 | 0.23 | |
| ASD | 82 (0.52) | 76 (0.48) | 0.98 | 17 | 41 | 20 | 0.46 | |
| Controls | 87 (0.52) | 81 (0.48) | 15 | 54 | 18 | |||
| rs3751285 | Intron 6 | A | G | |||||
| SCZ | 68 (0.77) | 20 (0.33) | 0.35 | 28 | 12 | 4 | 0.32§ | |
| ASD | 97 (0.71) | 39 (0.29) | 0.96 | 34 | 27 | 6 | 0.97 | |
| Controls | 106 (0.72) | 42 (0.28) | 39 | 31 | 6 | |||
| rs3751284 | Exon 6 | C | T | |||||
| SCZ | 58 (0.66) | 30 (0.34) | 0.35 | 20 | 18 | 6 | 0.45 | |
| ASD | 75 (0.55) | 61 (0.45) | 0.32 | 20 | 34 | 13 | 0.69 | |
| Controls | 88 (0.60) | 60 (0.40) | 26 | 39 | 11 | |||
| rs905721 | Intron 8 | C | T | |||||
| SCZ | 96 (0.70) | 42 (0.30) | 0.10 | 33 | 30 | 6 | 0.22 | |
| All SCZ | 353 (0.62) | 213 (0.38) | 0.92 | 114 | 125 | 44 | 0.86 | |
| ASD | 104 (0.66) | 54 (0.34) | 0.33 | 31 | 41 | 6 | 0.02 | |
| All ASD | 360 (0.64) | 198 (0.36) | 0.41 | 115 | 130 | 34 | 0.27 | |
| Controls | 98 (0.65) | 52 (0.35) | 37 | 24 | 14 | |||
| All controls | 309 (0.62) | 189 (0.38) | 102 | 105 | 42 | |||
| rs348624 and rs1964052 | Exon 9 and intron 9 | C and C | T and T | |||||
| SCZ | 121 (0.89) | 15 (0.11) | 0.48 | 54 | 13 | 1 | 0.49§ | |
| All SCZ | 500 (0.87) | 74 (0.13) | 0.34 | 218 | 63 | 6 | 0.50 | |
| ASD | 132 (0.85) | 24 (0.15) | 0.07 | 55 | 18 | 3 | 0.07§ | |
| All ASD | 472 (0.86) | 74 (0.14) | 0.22 | 206 | 60 | 7 | 0.39 | |
| Controls | 137 (0.91) | 13 (0.09) | 62 | 13 | 0 | |||
| All controls | 283 (0.89) | 34 (0.11) | 128 | 29 | 2 | |||
| rs164146 and rs164147 | Exon 10 | G and C | C and A | |||||
| SCZ | 104 (0.83) | 22 (0.17) | 0.71 | 43 | 18 | 2 | 0.73§ | |
| ASD | 133 (0.84) | 25 (0.16) | 0.99 | 56 | 20 | 2 | 0.91§ | |
| Controls | 128 (0.84) | 24 (0.16) | 57 | 23 | 1 | |||
*Polymorphisms included have a minor allele frequency above 0.05. # Markers are listed from centromere au telomere. § Fischer exact Test. Significant P values (<0.05) are in bold. Abbreviations: ASD: autism spectrum disorders, SCZ: schizophrenia.