Table 2.
Association between the MCF2L2 genetic polymorphisms and diabetic nephropathy
| SNP ID Hit Orientation |
Group | Genotype Frequency | Allele Frequency | Association Significance P-value/Odds ratio (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs35069869 | Women | AA | AG | GG | A | G | |
| A/G | T1D without DN | 174 (0.489) | 153 (0.430) | 29 (0.081) | 0.704 | 0.211 | |
| T1D with DN | 135 (0.509) | 109 (0.411) | 21 (0.079) | 0.715 | 0.285 | 0.661 a | |
| Men | |||||||
| T1D without DN | 125 (0.519) | 101 (0.419) | 15 (0.062) | 0.728 | 0.272 | ||
| T1D with DN | 150 (0.479) | 137 (0.438) | 26 (0.083) | 0.698 | 0.302 | 0.273 a | |
| rs35368790 | Women | GG | GC | CC | G | C | |
| G/C | T1D without DN | 168 (0.471) | 151 (0.423) | 38 (0.106) | 0.682 | 0.318 | |
| T1D with DN | 134 (0.511) | 107 (0.408) | 33 (0.105) | 0.716 | 0.284 | 0.204 a | |
| Men | |||||||
| T1D without DN | 107 (0.442) | 110 (0.455) | 25 (0.103) | 0.669 | 0.331 | ||
| T1D with DN | 146 (0.466) | 134 (0.428) | 33 (0.105) | 0.681 | 0.319 | 0.696 a | |
| rs7639705 | Women | TT | TG | GG | T | G | |
| T1165G | T1D without DN | 213 (0.603) | 125 (0.354) | 15 (0.043) | 0.780 | 0.220 | |
| Leu359Ile | T1D with DN | 188 (0.712) | 65 (0.246) | 11 (0.042) | 0.835 | 0.165 | 0.017/0.701 (0.524-0.938) a 0.018/0.757 b |
| Men | |||||||
| T1D without DN | 157 (0.651) | 73 (0.303) | 11 (0.046) | 0.803 | 0.197 | ||
| T1D with DN | 183 (0.590) | 115 (0.371) | 12 (0.039) | 0.776 | 0.224 | 0.275 a | |
T1D = type 1 diabetes, DN = diabetic nephropathy. Association significances = a. test for allele frequency difference (additive model), and b. for Armitage's trend.