Table 2.
Published studies analyzing parental strains using the QTL/Microarray approach in mouse
| Phenotype | QTL Mapping | Microarray Experiment | References | ||||
|---|---|---|---|---|---|---|---|
| Design | Strains | Design | Tissues | Platform | |||
| Targeted custom arrays | |||||||
| Arthritis | Congenic | RIIIS/J, B10.RIII | Congenic | Lymph nodes, spleen, paws | Custom | [100] | |
| Obesity | Congenic | SPRET/Ei, C57BL/6J | Parental | Brain, EWAT, GSM, liver | Nimblgen | [101] | |
| Whole-Genome arrays | |||||||
| • | Alcohol addiction | RIL | HAFT, LAFT | Parental | Brain | MGU74A | [39,102] |
| • | Alcohol addiction | RIL | C57BL/6J, DBA/2J | Parental | NAC, PFC, VTA | U74Av2 | [103] |
| Alcohol addiction | Congenic | ISS.ILS.Lore, ISS | Parental | CR | MO430A, MOE430B | [38,104] | |
| • | Anxiety | Knockout/congenic | B6.129-Il10-/-, C57BL/6J | Congenic | ABR | MOE430 | [105] |
| Anxiety | Database | - | Parental | PFC, VS, TL, PG, CR | Spotted | [106] | |
| • | Arthritis | AIL | DNA/1J, FVB/N | Parental | Lynph nodes | MOE430A | [107] |
| Arthritis | AIL | DNA/1J, FVB/N | Parental | Lynph nodes | U430A | [36] | |
| • | EIAD | F2/RIL | DBA/1, C57BL/6J | Extremes | Lung | NIA15k | [52] |
| • | Gallstones | BC | C57L/J, AKR/J | Parental | Liver | Spotted | [108,109] |
| • | HSCP | RIL, BC, Congenic | C57BL/6J, DBA/2J | Parental | HSC | Filter | [49] |
| • | IBD | BC | B6-Il10-/-, C3H-Il10-/- | Congenic | Colon | U74Av2 | [35,110] |
| Lung injury response | BC | A/J, C57BL/6J | Parental | Lung | Spotted | [29] | |
| • | Macronutrient intake | Congenic | C57BL/6J, CAST/EiJ | Congenic | Liver, hypothalamus | ABI | [103] |
| • | Obesity | Congenic | F-line, L-line | Congenic | Liver, BAT | Spotted | [111] |
| • | Obesity | BC | C57BL/6J, SPRET/Pt, SPRET/Ei | Extremes | EWAT | Spotted | [112] |
| • | Obesity | F2 | DU6i, DBA/2 | Parental | EWAT | Mu11k | [47] |
| • | Osteoporosis | Congenic | C57BL/6J, CAST/Ei | Congenic | Femur | Spotted | [28,113] |
| Osteoporosis | RI | C57BL/6J, CAST/Ei | Parental | Kidney | Spotted | [26,45] | |
| Platelet count | F2 | CBA/CaH, QSi5 | Parental | Liver, kidney, spleen | Spotted/Compugen Mouse 22K | [25] | |
| • | Pulmonary capacity | F2/BC | C3H/HeJ, JF1/Msf | Parental | Lung | Spotted/Operon | [114] |
| TR | BC/Introgression | A/J, C57BL/6J | Parental | Liver, kidney, spleen | MG-430v2 | [96,115] | |
| • | Type I diabetes | Congenic | NOD, Idd3, Idd5, Idd3+5, Idd9, B10, B10.H2g7, B10.H2g7Idd3 | Congenic | Thymus, Spleen | Affy.Eos.Custom | [116] |
Phenotype abbreviations: EIAD: Endotoxin-induced airway disease, HSCP: Hematopoietic stem cells proliferation, IBD: Inflammatory bowel disease, TR: Trypanosomiasis resistance. Tissue abbreviations: ABR: amigdala brain region, BAT: Brown adipose tissue, CR: cerebellum, GSM: gastrocnemius skeletal muscle, HSC: Hematopoietic stem cells, NAC: nucleus accumbens, PFC: Prefrontal cortex, PG: periaqueductal gray, TL: temporal lobe, VS: ventral striatum, VTA: ventral tegmental area. Strain abbreviations: HAFT: High Acute Functional Tolerance, ILS: Inbred Long Sleep, ISL: Inbred Short Sleep, LAFT: Low Acute Functional Tolerance. • Articles included in Table 3.