Figure 1.

Rag2^-/- female mice lost weight and died at late time points after primary infection. Female wild type or Rag2^-/- mice were infected with 2 × 10³ or 2 × 10⁵ FFU of influenza A virus PR8 (H1N1) as described [20] and weight loss (A) and survival (B) was recorded for the next 16 days. In addition to mice that were found dead, mice with a weight loss of more than 25% of the starting bodyweight were euthanized and recorded as dead.