Table 1.
Immunosuppressive Regimen
| Drugs | Dose | Timing |
|---|---|---|
| Induction | ||
| Anti CD20 | 19 mg/kg | Preop days −7 and 0 |
| ATG | 40–50 mg/kg | Preop days −2 and −1 |
| Anti CD154 | 25 mg/kg | Preop days −1 and 0 |
| CVF | 50–100 U/kg | Preop days −1 and 0 |
| Maintenance | ||
| Anti CD20 | 19 mg/kg | Postop days 7 and 14 |
| Anti CD154 | 25 mg/kg | Postop days 3, 7, 10, 14, and 19, q weekly |
| CVF | 50 U/kg | Postop day 1 |
| MMF | 20 mg/kg/2 hr IV infusion | BID daily |
| Steroids | 2 mg/kg | BID, tapered off in 7 weeks |
| Aspirin | 81 mg | Daily |
| Heparin | Maintain ACT 2× baseline | Continuous infusion |
| Supportive | ||
| Ganciclovir | 5 mg/kg/d | Daily |
| Cefazolin | 250 mg | BID for 7 days |
| Epogen | 200 U/kg | Daily from day −7 to 7, then weekly |
| Ketorolac | 15 mg | Just before anti-CD154 |