Table 4.

Association of Serum Albumin With Incident Heart Failure: Subgroup Analyses

	Albumin (g/L)	Univariate HR* (95% CI)	P value	Multivariate† HR* (95% CI)	P value
Race
White (N=1707)	39.9 (0.31)	1.13 (1.04–1.22)	0.003	1.13 (1.04–1.22)	0.004
Black (N=1200)	39.6 (0.31)	1.14 (1.06–1.23)	0.001	1.13 (1.04–1.22)	0.003
Gender
Male (N=1394)	40.0 (0.32)	1.14 (1.06–1.23)	0.001	1.13 (1.05–1.23)	0.002
Female (N=1513)	39.6 (0.30)	1.14 (1.05–1.23)	0.001	1.12 (1.04–1.22)	0.005

^*HR: hazard ratio per -1g/L baseline albumin concentration

^†Multivariate model including clinical predictors of heart failure, inflammatory markers, and incident coronary events

Interaction for race: univariate, P=0.72; multivariate, P=0.97

Interaction for gender: univariate, P=0.86; multivariate, P=0.82

The time-dependent decrease in the albumin hazard ratio over time was similar across all race- and gender-based subgroups, diminishing by approximately 2.0% per year (95% CI, 1.7–2.3)