Table 3.
DTI differences between NPSLE patients and controls
FA Controls > NPSLE | ||||||
---|---|---|---|---|---|---|
Voxels | p-value | Max-t | MNI X | MNI Y | MNI Z | Approximate white matter tract |
266 | 0.001 | 3.135 | 30 | 17 | 18 | Right superior longitudinal fasciculus |
223 | 0.001 | 3.242 | 11 | -34 | 25 | Splenium of CC |
172 | 0.003 | 3.408 | -8 | 5 | 25 | Body of CC |
165 | 0.003 | 3.028 | -26 | 28 | 12 | Left anterior corona radiata |
120 | 0.006 | 3.006 | 34 | -41 | 28 | Right superior longitudinal fasciculus |
MD NPSLE > Controls | ||||||
Voxels | p-value | Max-t | MNI X | MNI Y | MNI Z | Approximate white matter tract |
454 | < 0.001 | 3.201 | -35 | -28 | 30 | Left superior longitudinal fasciculus |
426 | < 0.001 | 3.028 | -24 | 15 | 19 | Left anterior corona radiata |
214 | 0.001 | 4.027 | 22 | -19 | 37 | Right superior corona radiata |
193 | 0.001 | 3.195 | 30 | 0 | 28 | Right superior longitudinal fasciculus |
130 | 0.002 | 3.624 | 27 | -42 | 33 | Right superior longitudinal fasciculus |
119 | 0.002 | 4.09 | -2 | -9 | 10 | Left anterior thalamic radiation |
103 | 0.003 | 3.738 | -23 | -56 | 21 | Left arm of forceps major |
100 | 0.003 | 3.074 | -28 | 24 | 21 | Left anterior thalamic radiation |
97 | 0.003 | 4.055 | 29 | 20 | 18 | Right inferior fronto-occipital fasciculus |
88 | 0.004 | 3.867 | 25 | -53 | 18 | Splenium of CC |
73 | 0.007 | 3.167 | -8 | -29 | 24 | Body of CC |
64 | 0.009 | 3.128 | 33 | -17 | 26 | Right superior longitudinal fasciculus |
DTI differences between NPSLE patients and controls. Upper section lists significant regions in which controls had greater fractional anisotropy (FA) than NPSLE patients. Lower panel lists regions in which NPSLE patients had greater mean diffusivity (MD) than control subjects. Voxels = significant contiguous voxel cluster. Max-t = t statistic of voxel cluster difference between controls and NPSLE. MNI X, Y, Z = Montreal Neurological Institute coordinates of centroid location of significant voxel cluster. CC = corpus callosum.