Table 2.

Pharmacological treatments with known behavioural effects on adult zebrafish.

Behaviour	Modulating agent	Function / Activity	Effect	Reference
Aggression	Ethanol	GABA-A receptor modulator	Increases aggression	[85]
Aggression	17α-ethinylestradiol	Synthetic oestrogen	Reduces aggression	[44]
Antipredation	Ethanol	GABA-A receptor modulator	Impaired by high doses	[6]
Anxiety	Diazepam	Benzodiazepine	Reduces anxiety	[49,86]
Anxiety	FG-7142	Benzodiazepine inv. agonist	Increases anxiety	[49]
Anxiety	Pentylenetetrazole	GABA antagonist	Increases anxiety	[53]
Anxiety	Ethanol	GABA-A receptor modulator	Reduces anxiety	[50,53]
Anxiety	Buspirone	Htr1A partial agonist	Reduces anxiety	[55]
Anxiety	Alarm substance	Hypoxanthine-3N-oxide	Increases anxiety	[50,52]
Anxiety	Nicotine	NachR agonist	Reduces anxiety	[34]
Anxiety	Methyllycaconitine	Nicotinic antagonist	Anxiolytic	[55]
Anxiety	Dihydro-β-erythroidine	Nicotinic antagonist	Anxiolytic	[55]
Anxiety	Mecamylamine	Nicotinic antagonist	Anxiolytic	[34]
Anxiety	Morphine	Opiate	Reduces anxiety	[53]
Anxiety	Cocaine (withdrawal)	Psychostimulant	Increases anxiety	[49]
Anxiety	Fluoxetine	5-HT reuptake inhibitor	Reduces anxiety	[50,53]
Anxiety	Caffeine	Xanthine alkaloid	Increases anxiety	[50,53]
Group preference	Ethanol	GABA-A receptor modulator	Reduced at high conc.	[6]
Learning	α FMH	HDAC inhibitor	Impairs long term memory	[30]
Learning	Nicotine	NachR agonist	Improves learning	[34,35]
Learning	MK-801	NMDA antagonist	Impairs memory	[27,28]
Learning	L-NAME	NO synthase inhibitor	Impairs memory retention	[27]
Light/Dark pref	Ethanol	GABA-A receptor modulator	Decreased at high conc.	[6]
Locomotion	Ethanol	GABA-A receptor modulator	Reduced at high conc.	[6]
Reward	Acetylcholine	Cholinergic agonist	Non-rewarding	[13]
Reward	Ethanol	GABA-A receptor modulator	Rewarding	[7]
Reward	Nicotine	NachR agonist	Rewarding	[7]
Reward	Food	Nourishment	Rewarding	[10]
Reward	Morphine	Opiate	Rewarding	[10]
Reward	Morphine	Opiate	Rewarding	[10]
Reward	Cocaine	Psychostimulant	Rewarding	[8]
Reward	Amphetamine	Psychostimulant	Rewarding	[9]
Sleep	Dexmedetomidine	alpha2 adrenoceptor agonist	Sedative	[61]
Sleep	Pentobarbital	Barbiturate	Hypnotic	[57]
Sleep	Diazepam	Benzodiazepine	Hypnotic	[57]