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T1ρ maps of the medial temporal lobe (MTL) region in the brain (in color) overlaid on fluid-attenuated T1ρ MRI of control (70 Y female, A), MCI (69 Y male, B), and AD patient (84 Y female, C). Pixels with higher T1ρ (red) are more prominent in MTL of AD patient. Increase in sulcal space in AD patients suggesting greater degree of brain atrophy. A lack of signal from CSF implies that the higher T1ρ values are not due to fluid.
