Table 4.

Risk of preterm birth, low birth weight, and small-for-gestational-age by age of cancer diagnosis of mother, expressed as odds ratios (ORs) comparing offspring of cancer survivors to offspring of female siblings

		Cancer Suvivors Age at Diagnosis		Siblings
Birth outcome	0–14 yrs	15–19 yrs	20–34 yrs
	N=297	N=249	N=763
Preterm<37wks N	25	19	58	298/5916
Crude OR (95% CI‡)	1.73 (1.13–2.65)	1.56 (0.96–2.52)	1.55 (1.16–2.08)	1.00
Adjusted OR* (95% CI)	1.62 (1.05–2.51)	1.56 (0.96–2.55)	1.36 (1.01–1.85)	1.00
Preterm<34wks N	9	5	17	71/5916
Crude OR (95% CI)	2.57 (1.27–5.20)	1.69 (0.68–4.22)	1.88 (1.10–3.20)	1.00
Adjusted OR* (95% CI)	2.38 (1.15–4.94)	1.74 (0.68–4.40)	1.53 (0.87–2.67)	1.00
Low Birth Weight N	21	14	45	221/5913
Crude OR (95% CI)	1.96 (1.23–3.12)	1.53 (0.88–2.67)	1.61 (1.16–2.24)	1.00
Adjusted OR† (95% CI)	1.61 (0.80–3.21)	0.88 (0.38–2.04)	1.03 (0.63–1.67)	1.00
Small-for-gestational-age N	7	9	21	162/5913
Crude OR (95% CI)	0.86 (0.40–1.84)	1.33 (0.67–2.64)	1.00 (0.63–1.59)	1.00
Adjusted OR* (95% CI)	0.70 (0.32–1.52)	1.18 (0.59–2.37)	0.87 (0.54–1.41)	1.00

^*Adjusted for maternal age, delivery year, child gender, maternal smoking, maternal hypertension, placental problems, use of assisted reproductive technologies, malpresentation and cesarean delivery

^†Additionally adjusted for gestational weeks

^‡95% Confidence interval