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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Int J Cancer. 2010 Oct 1;127(7):1669–1679. doi: 10.1002/ijc.25157

Table 7.

Summary of recent studies on preterm birth and low birth weight (LBW) among children of female cancer survivors

Authors & year Age at cancer diagnosis Treatment period Comparison group Patients N Pregnancies N Outcome Determination Preterm OR (95% CI) LBW OR (95% CI) Comments
Mueller et al.12 2009 0–19 1973–2000 General population 1898 1898 Registry linkage 1.54 (1.30–1.83) 1.31 (1.10–1.57) Migration in or out of reporting area not known
Reulen et al.13 2009 0–15 1940–1991 General population 1991 4113 Questionnaire 3.2 (2.1–4.7)* 1.9 (1.1–3.2)* Only pediatric patients
Clark et al.10 2007 0–43 1980–2005 General population 917 1 122 Registry linkage 1.33 (1.01–1.76) 1.03 (0.77–1.37) No diagnostic-age specific risk estimates
Signorello et al.9 2006 0–20 1970–1986 Sample of female siblings 1264 3529 Questionnaire 1.9 (1.4–2.4) 1.3 (0.9–1.9) Non-random selection of comparison group
Green et al.19 2002 0–20 1970–1986 Sample of female siblings 1915 4029 Questionnaire NA 2.05 (1.42–2.95) No adjustment for gestational age
Chiarelli et al.18 2000 0–19 1964–1988 Patients treated with non-sterilising surgery only 340 340 Questionnaire 3.64 (1.33–9.96) 3.29 (0.97–11.1) Only pediatric patients
*

Among female cancer survivors treated with abdominal radiotherapy.