Table 7.
Summary of recent studies on preterm birth and low birth weight (LBW) among children of female cancer survivors
| Authors & year | Age at cancer diagnosis | Treatment period | Comparison group | Patients N | Pregnancies N | Outcome Determination | Preterm OR (95% CI) | LBW OR (95% CI) | Comments |
|---|---|---|---|---|---|---|---|---|---|
| Mueller et al.12 2009 | 0–19 | 1973–2000 | General population | 1898 | 1898 | Registry linkage | 1.54 (1.30–1.83) | 1.31 (1.10–1.57) | Migration in or out of reporting area not known |
| Reulen et al.13 2009 | 0–15 | 1940–1991 | General population | 1991 | 4113 | Questionnaire | 3.2 (2.1–4.7)* | 1.9 (1.1–3.2)* | Only pediatric patients |
| Clark et al.10 2007 | 0–43 | 1980–2005 | General population | 917 | 1 122 | Registry linkage | 1.33 (1.01–1.76) | 1.03 (0.77–1.37) | No diagnostic-age specific risk estimates |
| Signorello et al.9 2006 | 0–20 | 1970–1986 | Sample of female siblings | 1264 | 3529 | Questionnaire | 1.9 (1.4–2.4) | 1.3 (0.9–1.9) | Non-random selection of comparison group |
| Green et al.19 2002 | 0–20 | 1970–1986 | Sample of female siblings | 1915 | 4029 | Questionnaire | NA | 2.05 (1.42–2.95) | No adjustment for gestational age |
| Chiarelli et al.18 2000 | 0–19 | 1964–1988 | Patients treated with non-sterilising surgery only | 340 | 340 | Questionnaire | 3.64 (1.33–9.96) | 3.29 (0.97–11.1) | Only pediatric patients |
*
Among female cancer survivors treated with abdominal radiotherapy.