Table 5.
Association of CAD risk factors and regional adiposity measures with CAD status in men and women with type 1 diabetes - The Pittsburgh Epidemiology of Diabetes Complications Study (N=163)
| FEMALES | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1a | Model 2 | Model 3 | Model 4 | |||||||||
| Variable | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p |
| Age (years) | 1.14 | 1.03–1.25 | .01 | 1.15 | 1.03–1.27 | .01 | 1.13 | 1.03–1.25 | .01 | 1.15 | 1.04–1.29 | .01 |
| HDLc | 0.62 | 0.32–1.20 | .16 | 0.69 | 0.36–1.35 | .28 | 0.62 | 0.32–1.20 | .16 | 0.70 | 0.36–1.35 | .28 |
| History of Smoking | 1.64 | 0.46–5.93 | .45 | 1.99 | 0.51–7.74 | .32 | 1.65 | 0.46–5.92 | .44 | 1.98 | 0.50–7.85 | .33 |
| Height | 0.46 | 0.23–0.90 | .02 | 0.45 | 0.22–0.92 | .03 | 0.45 | 0.23–0.90 | .02 | 0.46 | 0.22–0.94 | .03 |
| eGDR | 1.08 | 0.55–2.12 | .83 | 1.38 | 0.65–2.95 | .40 | 1.10 | 0.56–2.20 | .78 | 1.42 | 0.66–3.06 | .37 |
| Total FM | 1.56 | 0.80–3.01 | .19 | 1.16 | 0.55–2.45 | .69 | 1.50 | 0.77–2.92 | .23 | 0.96 | 0.41–2.21 | .91 |
| % FM in Legs | 0.40 | 0.16–0.99 | .05 | |||||||||
| % FM in Arms | 1.26 | 0.63–2.50 | .51 | |||||||||
| % FM in Trunk | 2.79 | 1.08–7.20 | .03 | |||||||||
| AIC | 80.5 | 77.8 | 82.0 | 77.2 | ||||||||
| MALES | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | |||||||||
| Variable | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p |
| Age (years) | 1.15 | 1.04–1.28 | .01 | 1.15 | 1.04–1.28 | .01 | 1.16 | 1.05–1.28 | .01 | 1.15 | 1.04–1.28 | <.01 |
| Serum Creatinine | 1.53 | 0.88–2.65 | .13 | 1.52 | 0.87–2.64 | .14 | 1.53 | 0.88–2.65 | .13 | 1.52 | 0.88–2.64 | .14 |
| History of Smoking | 1.18 | 0.38–3.62 | .77 | 1.20 | 0.39–3.71 | .75 | 1.22 | 0.40–3.77 | .73 | 1.19 | 0.38–3.70 | .76 |
| Height | 0.67 | 0.38–1.16 | .15 | 0.67 | 0.39–1.17 | .16 | 0.65 | 0.37–1.15 | .14 | 0.67 | 0.39–1.17 | .16 |
| eGDR | 0.83 | 0.43–1.57 | .56 | 0.86 | 0.43–1.75 | .68 | 0.83 | 0.44–1.58 | .57 | 0.84 | 0.42–1.68 | .62 |
| Total FM | 1.14 | 0.64–2.05 | .65 | 1.11 | 0.61–2.04 | .73 | 1.17 | 0.65–2.10 | .60 | 1.12 | 0.57–2.18 | .75 |
| % FM in Legs | 0.90 | 0.46–1.78 | .76 | |||||||||
| % FM in Arms | 0.84 | 0.47–1.51 | .56 | |||||||||
| % FM in Trunk | 1.06 | 0.49–2.26 | .89 | |||||||||
| AIC | 95.2 | 97.1 | 96.9 | 97.2 | ||||||||
Model 1: Includes significant univariate variables (age and HDLc in women, age and serum creatinine in men) and potential confounders (history of smoking, height, eGDR and Total FM)
Model 2: Includes Model 1 variables and % FM in Legs
Model 3: Includes Model 1 variables and % FM in Arms
Model 4: Includes Model 1 variables and % FM in Trunk
Odds ratios are per 1 SD increase, except for age (per 1 yr increase) and history of smoking (yes)
Abbreviations: CAD, coronary artery disease; OR, odds ratio; CI, confidence interval; eGDR, estimated glucose disposal rate; FM, fat mass; AIC, Akaike's Information Criteria