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. Author manuscript; available in PMC: 2011 Aug 11.
Published in final edited form as: Structure. 2010 Jul 15;18(8):1032–1043. doi: 10.1016/j.str.2010.05.007

Figure 4.

Figure 4

Structural basis of 5′ triphosphate dsRNA recognition by RIG-I CTD. (A) Stereo close up of the interface between RIG-I CTD (Chain A) and the terminus of the 14-bp 5′ ppp dsRNA. RIG-I CTD is shown as cyan ribbons and the dsRNA is shown as stick models. Key residues of RIG-I CTD involved in RNA binding are shown as stick models. (B) Stereo close up of the interactions between RIG-I CTD and the 5′ triphosphate of the 14-bp GC-rich dsRNA. (C) Surface representation of RIG-I CTD bound to 5′ ppp dsRNA showing the shape and charge complementarity between RIG-I CTD and the terminus of the 5′ ppp dsRNA. Positively charged surfaces are colored blue and negatively charged surfaces are red. The orientation of RIG-I CTD relative to the dsRNA on the left panel is similar to the orientation of the protein in panel A.