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Similar binding surfaces of RIG-I CTD mediate the interactions with different forms of RNA. (A) Binding studies of wild type and mutants of RIG-I CTD for the 14-bp 5′ ppp dsRNA by electrophoretic mobility shift assay (EMSA). (B) Binding studies of RIG-I CTD mutants with a 14-bp blunt-ended dsRNA lacking 5′ triphosphate. (C) Binding studies of RIG-I CTD mutants with a 13-nt 5′ ppp ssRNA.
