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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Semin Cell Dev Biol. 2010 Mar 6;21(7):745–753. doi: 10.1016/j.semcdb.2010.03.001

Figure 3. Processes regulated by Drosophila miR-8.

Figure 3

(A) miR-8 prevents neurodegeneration in the brain by limiting levels of the transcriptional corepressor atrophin. (B) Though not demonstrated under endogenous circumstances, miR-8 is able to repress Wg/Wnt signalling in the developing wing and eye by inhibiting of wntless, which encodes a transmembrane protein required for secretion of Wg; it can also repress CG32767, a positive regulator of Wg/Wnt signalling. (C) During larval growth, miR-8 represses the zinc finger protein encoded by u-shaped in the fat body to promote organismal growth. (D) Finally, miR-8 controls the morphology of neuromuscular junctions by acting in muscles to repress enabled, an EVH1/PH domain regulator of synapse development.