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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Jul 20;19(8):2106–2109. doi: 10.1158/1055-9965.EPI-10-0515

Table 1.

Age-adjusted odds ratios (OR) and 95% confidence intervals for the association between candidate polymorphisms and endometrial cancer risk in four independent case-control studies

Study Cases Controls FTO rs12927155 Cases Controls HHEX rs1111875
Per allele Per allele
N N MAF1 OR (95% CI) p-value N N MAF1 OR (95% CI) p-value
PECS 417 406 0.17 1.53 (1.19–1.97) 0.001 417 406 0.42 0.80 (0.66–0.97) 0.026
SEARCH 1121 1596 0.16 1.01 (0.85–1.21) 0.88 1119 1591 0.41 1.01 (0.88–1.14) 0.93
ANECS 1022 896 0.15 0.89 (0.74–1.08) 0.24 992 898 0.40 1.01 (0.88–1.15) 0.91
LES2 204 648 0.16 1.08 (0.70–1.68) 0.72 0 0
Pooled3 2347 3140 0.15 0.94 (0.83–1.06) 0.29 2111 2489 0.40 1.00 (0.92–1.10) 0.96
1

MAF=minor allele frequency among controls

2

rs1111875 was not genotyped in LES

3

Pooled estimates were calculated for the three replication studies (SEARCH, ANECS, and LES); therefore, models were also adjusted for study. Numbers do not sum to the total samples available because of missing genotype data.