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. Author manuscript; available in PMC: 2011 Jul 27.
Published in final edited form as: ACS Nano. 2010 Jul 27;4(7):3679–3688. doi: 10.1021/nn901796n

Figure 2.

Figure 2

AFM images (panels a and b) and TEM image (panel C) of siRNA nanoparticles formed from 0.4 μM 21 bp siRNA in the presence of Au NPs modified with G3 PPI dendrimer (2.5 μM). (A) AFM image, z range= 20.0 nm; (B) phase image, z range=40 degree. The bar represents 100 nm in panels (A) and (B). (C) TEM image of NPs. The bar represents 50 nm in panel C. AFM phase image and TEM image clearly show the Au NPs (indicated by white arrows) were not included in the siRNA nanoparticles (indicated by green arrows). (D) AFM images of siRNA nanostructures formed from G3 alone with the same concentration of siRNA and G3 PPI as in the case of Au NPs modified with G3 PPI dendrimer. The bar represents 500 nm in panels (D)