Table 1.
Characteristics for the AD group and the group of healthy elderly individuals
| AD | HC | Group difference | |
|---|---|---|---|
| Demographics | |||
| Number | 38 | 34 | |
| Age | 76 ± 7 | 77 ± 8 | ns |
| Gender (F/M) | 23/15 | 24/10 | ns |
| MMSE | 19 ± 5 | 29 ± 1 | P < 10-12 |
| APOE ε4 heterozygote (homozygote) | 63% (13%) | 24% (3%) | P < 10-4 |
| CSF** | |||
| Aβ42 | 307 ± 91 | 647 ± 166 | P < 10-11 |
| T-tau | 938 ± 542 | 399 ± 194 | P < 10-8 |
| P-tau | 106 ± 55* | 64 ± 28 | P < 10-4 |
| MMP-1 | 0.024 ± 0.016 | 0.021 ± 0.01 | ns |
| MMP-3 | 0.716 ± 0.35 | 0.700 ± 0.36 | ns |
| MMP-9 | 0.902 ± 0.39 | 0.859 ± 0.35 | ns |
| TIMP-1 | 0.035 ± 11.7 | 0.041 ± 13.0 | P < 0.05 |
| MMP-1/TIMP-1 | 0.697 ± 0.35 | 0.564 ± 0.25 | ns |
| MMP-3/TIMP-1 | 21.1 ± 9.7 | 18.1 ± 9.8 | ns |
| MMP-9/TIMP-1 | 26.9 ± 11.9 | 22.7 ± 11.8 | P < 0.05 |
Aβ42, β-amyloid1-42; AD, Alzheimer's disease; APOE, apolipoprotein E; CSF, cerebrospinal fluid; F, female; HC, healthy controls; M, male; MMP, matrix metalloproteinase; MMSE, mini mental state examination; TIMP, tissue inhibitor of metalloproteinase.
* n = 28. ** Levels are in ng/l for Aβ42, T-tau and P-tau and in ng/ml for the MMPs and TIMP-1.