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. 2010 Apr 5;38(14):4586–4598. doi: 10.1093/nar/gkq214

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — M. xanthus CarD and the PF02559 protein family. (A) Schematic showing CarD domain architecture. Residue numbers (on top) demarcate the distinct regions. The CarD N-terminal domain, CarDNter, defines the PF02559 family that includes a number of CarDNter-like proteins and TRCF-RID. CarDCter denotes the HMGA-like CarD C-terminal domain, with human HMGA1a shown for comparison (‘+’ indicate the basic AT-hooks and ‘−’ the acidic region). (B) Sequence alignment of representative PF02559 family members. NCBI accession codes and the corresponding bacterium are indicated in brackets: CarDNter (CAA91224; M. xanthus); CdnL (YP_630846; M. xanthus); TRCF-RID, the segment corresponding to residues 514–587 of TRCF (YP_629274; M. xanthus); BbCdnL (NP_969149; B. bacteriovorus); CgCdnL (YP_001139479; C. glutamicum); ScCdnL (NP_628406; S. coelicolor); TtCdnL (YP_005787; T. thermophilus). Residues are shaded black (with an asterisk in the consensus line below) when identical in the majority of the aligned sequences, or grey when similar.