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Binding mode of Orlistat in the TE domain of FASN. Only the molecular surface of the TE domain where Orlistat binds is shown. The binding of Orlistat in the TE domain exists as a serine adduct intermediate (pink ball and stick, panel A) and hydrolyzed product (gray ball and stick, panel B). The serine intermediate is also superimposed to show the shifts and changes in the hydrolyzed product in panel B. This figure was generated from data in PDB (ID: 2PX6).
