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The concentration dependent transport of 8-FcA by OATP1B1 (A) and OATP1B3 (B). The 8-FcA concentration ranged from 0.25 μM to 25 μM and the period of uptake for each transporter was 10 minutes. The Km and Vmax for each transporter is indicated in the figure. The fit of the kinetic data is shown as a solid line. Data represent the mean and standard error of three experiments where each concentration was performed in triplicate.
