Table 3.

Longitudinal analysis of pulmonary function in 89 survivors of childhood hematologic malignancies who received allogeneic HSCT

Tests	Factors	P value	Estimates of slope
Obstructive values
FEV1/FVC	Male	0.026	−2.6554
	Recipient age (year)	0.0004	−0.5444
	Years from HSCT	0.0001	−0.2482
FEV1	Respiratory event (<1yr after HSCT)	0.003	−11.4091
FEF25%–75%	Recipient age (year)	< 0.0001	−2.4812
	Years from HSCT	< 0.0001	−1.909
Air trapping values
RV	Female	0.0039	−18.7051
	Years from HSCT	< 0.0001	−3.369
RV/TLC	Respiratory event (<1yr after HSCT)	0.014	4.1278
	Recipient age (year)	< 0.0001	0.6059
	Years from HSCT	0.0039	−0.2847
FRC	Years from HSCT	< 0.0001	−2.347
Restrictive values
FVC	Respiratory event (<1yr after HSCT)	0.003	−11.7654
	Female	0.015	−6.9235
TLC	Female	0.033	−6.6557
	Years from HSCT	< 0.0001	−1.179
Diffusion values
DLCOcorr	Years from HSCT	< 0.0001	−2.544
	Recipient age (year)	< 0.0001	−2.015

DLCO_corr indicates diffusion capacity corrected for hemoglobin; FEF_25–75%, forced mid-expiratory flow; FEV_1, forced expiratory volume in 1 second; FVC, forced vital capacity; FRC, functional residual capacity; GVHD, graft versus host disease; HSCT, hematopoietic stem cell transplantation; RV, residual volume; TLC, total lung capacity