Table 2.

Rank order of Aβ 40 and Aβ 42 levels in cortical regions of AD brain.

Group	Order of brain regions	Group	Order of brain regions
	Insoluble Aβ 40		Insoluble Aβ 40
SAD	F≈O>P>T	Controls, 83–94 ys	F>>O>P≈T
	(3819; 3751; 2979; 2326)		(249; 55; 15; 13)
APPsw	F>O>P>T	Controls, 58–74 ys	F>>O≈T≈P
	(4095; 3799; 2085; 1767)		(32; 4.1; 3.4; 2.4)
PS1	O>>T≈F>P	Controls, 41–49 ysa	F>T≈P
	(1624; 582; 525; 353)		(2.0; 1.4; 1.4)
	Soluble Aβ 40		Soluble Aβ 40
SAD	P≈O≈F>T	Controls, 83–94 ys	T≈F>P>O
	(322; 306; 296; 225)		(9.6; 9.5; 6.4; 4.3)
APPsw	O>F>P≈T	Controls, 58–74 ys	T>P>F≈O
	(358; 284; 238; 231)		(3.9; 1.8; 0.5; 0.5)
PS1	O>P>T>F	Controls, 41–49 ysa	T>P≈F
	(277; 217;185; 99)		(0.5; 0.2; 0.1)
	Insoluble Aβ 42		Insoluble Aβ 42
SAD	F>O≈T>P	Controls, 83–94 ys	F>>T>P>>O
	(1379; 1117; 1094; 707)		(203; 122; 91; 8.0)
APPsw	O>F>T>P	Controls, 58–74 ys	F>>T>P>O
	(809; 708; 575; 432)		(219; 128; 16.9; 8.2)
PS1	F>O≈T>P	Controls, 41–49 ysa	T>P>F
	(942; 504; 465; 260)		(13.2; 9,1; 4.3)
	Soluble Aβ 42		Soluble Aβ 42
SAD	P>T>F>O	Controls, 83–94 ys	T>F≈P>O
	(11.6; 8.5; 7.4; 6.5)		(8.6; 3.5; 3.5; 0.7)
APPsw	P≈T≈O>F	Controls, 58–74 ys	T>P>F>O
	(8.9; 8.0; 7.2; 4.7)		(4.5; 3.5; 2.1; 0.6)
PS1	P≈T>F≈O	Controls, 41–49 ysa	T>P≈ F
	(7.6; 6.5; 4.6; 4.3)		(0.9; 0.1; 0.0)

Mean values are given in parenthesis as pg/mg tissue. F, frontal: T, temporal; P, parietal, O, occipital cortex

^aOccipital cortex from the youngest control group was not available