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. 2010 Apr 14;30(15):5334–5345. doi: 10.1523/JNEUROSCI.5963-09.2010

Figure 5.

Figure 5.

A–J′, Loss of CXCR4 expression in deep migratory interneurons of Dlx5/6−/− mutants at E13.5. Coronal sections from Dlx5/6+/+ (A, C, E, G, I) and Dlx5/6−/− (B, D, F, H, J) were labeled by in situ hybridization against SDF1, Reelin, CXCR7 (RDC1), ErbB4 and CXCR4.Boxed areas are shown below in high magnification. The expression of SDF1 and reelin was maintained in Dlx5/6−/− mutants (B, D). The cavity formed by the everted exencephalic cortex contained scattered SDF1+ cells (* in B'). Although the expression of CXCR7 and ErbB4 was intact, CXCR4 expression was not detected in deep migratory interneurons (arrows in E′, F′, G′, H′, I′, J′). Scale bar: (in A) A–J′, 300 μm.