Table II.

Logistic Regression Model for Genetic Risk Score-5 in Angiographic Case/Control Set

Gene / locus (rs)	Risk Allele	ϐ	Sig	OR (95% CI)
CELSR2 / rs599839	Major	0.223	<0.001	1.25 (1.11–1.40)
9p21.3 / rs2383206	Minor	0.191	<0.001	1.21 (1.09–1.34)
CETP / rs289715*	Major	0.217	0.005	1.24 (1.07–1.44)
ApoF / rs78739461*	Minor	0.307	0.015	1.36 (1.06–1.74)
F2 (PT) / rs1799963	Major	0.474	0.046	1.61 (1.01–2.56)

ϐ =beta coefficient; Sig= significance (p-value); OR=odds ratio for angiographic CAD; CI=confidence interval.

^*Internally-discovered SNP. Candidate SNPs contributing trend associations in the multivariable model (0.05>p<0.2) but eliminated in the final model were: ApoC1/E rs4420638, CETP rs180075, CRP rs2794520, GCKR rs780094, and LIPC rs36041167. Effect estimates are for all variables considered simultaneously in the model.