Table II.
Gene / locus (rs) | Risk Allele | ϐ | Sig | OR (95% CI) |
---|---|---|---|---|
CELSR2 / rs599839 | Major | 0.223 | <0.001 | 1.25 (1.11–1.40) |
9p21.3 / rs2383206 | Minor | 0.191 | <0.001 | 1.21 (1.09–1.34) |
CETP / rs289715* | Major | 0.217 | 0.005 | 1.24 (1.07–1.44) |
ApoF / rs78739461* | Minor | 0.307 | 0.015 | 1.36 (1.06–1.74) |
F2 (PT) / rs1799963 | Major | 0.474 | 0.046 | 1.61 (1.01–2.56) |
ϐ =beta coefficient; Sig= significance (p-value); OR=odds ratio for angiographic CAD; CI=confidence interval.
Internally-discovered SNP. Candidate SNPs contributing trend associations in the multivariable model (0.05>p<0.2) but eliminated in the final model were: ApoC1/E rs4420638, CETP rs180075, CRP rs2794520, GCKR rs780094, and LIPC rs36041167. Effect estimates are for all variables considered simultaneously in the model.