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SOD1-induced IL-1β maturation correlates with its amyloid-like misfolding. (A) Th-T fluorescence of the indicated SOD1 proteins. (B) IL-1β maturation induced by the indicated SOD1 proteins in primed BMMs determined by ELISA. (C) Correlation of IL-1β maturation and its corresponding Th-T fluorescence at 490 nm. P = 0.0052; Pearson´s correlation coefficient r = 0.8027. AU, arbituary units. Data are representative of two independent experiments.
