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. 2010 Jul 6;107(29):13075–13080. doi: 10.1073/pnas.1004594107

Fig. 5.

Fig. 5.

Inhibition of Btk reduces renal disease and autoantibody production in MRL-Fas(lpr) mice. (A) Eight-week-old MRL-Fas(lpr) mice (n = 12) were randomized and treated orally with PCI-32765 or vehicle once daily for 12 wk at different concentrations as indicated. Range of urine protein concentration is calculated as a proteinurea score. Proteinurea scores from PCI-32765 treatments were significantly lower than vehicle group (**P < 0.01 for 3.125 mg/kg and ***P < 0.001 for 12.5 and 50 mg/kg treatments; repeated-measure ANOVA). (B) Serum BUN in PCI-32765–treated and vehicle-treated mice (***P < 0.001). (C) dsDNA-specific IgG in PCI-32765 treated and vehicle treated mice. (D) Histopathology scores at week 20 from the animals shown in A. Scores are mean ± SEM (n = 12; *P < 0.05).